Water spots - are they permanent? Impact on grade?

Reading Rick Tomaska's "The Complete Guid to Franklin Half Dollars" and he writes about water spots being common on unc halves beginning in 1953... particularly on Denver mint coins. Can water spots be removed? Can a coin grade MS 65 or better with water spots?
<a target=new class=ftalternatingbarlinklarge href="http://www.mullencoins.com">Mullen Coins Website - Windycity Coin website
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Russ, NCNE